Livedoid vasculitis - Vasculitis Livedoid
Vasculitis Livedoid (Livedoid vasculitis) waa cudur dabadheeraad ah oo maqaarka ku dhaca oo lagu arko inta badan haweenka da'da yar iyo kuwa dhexe. Mid ka mid ah ereyada la soo gaabiyey ee loo isticmaalo in lagu qeexo sifooyinkiisa ayaa ah "Nabarrada purpuric-ka ee xanuunka leh ee leh qaabka cirridaha hoose" (PURPLE). Waxay la xiriirtaa dhowr cudur, oo ay ku jiraan dhiig-karka xididdada dabadheeraad ah iyo varicosities.
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References
Livedoid vasculopathy waa xaalad maqaarka ah oo naadir ah oo lagu garto boogo xanuun badan oo ku soo noqnoqda lugaha hoose.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy waa maqaar naadir ah oo sababa nabarro ku soo noqnoqda lugaha hoose, ka taga nabarro cirro leh oo loo yaqaan 'atrophie blanche. Inkastoo sababta dhabta ah aysan weli caddayn, waxaa la rumeysan yahay in xinjirowga dhiigga ee kordhay (hypercoagulability) uu yahay qodobka ugu weyn, iyadoo caabuqa uu ka ciyaarayo door labaad. Waxyaalaha ka qayb qaata xinjirowga waxaa ka mid ah kuwan soo socda - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Ka-qaadista, xaaladdu waxay muujinaysaa xinjirowga dhiigga ee xididdada, dhumucyada derbiyada xididdada, iyo nabarro. Daawadu waxay ku lug leedahay habab dhinacyo badan leh oo diiradda saaraya ka hortagga xinjirowga dhiigga ee dawooyinka sida dawooyinka ka hortagga platelet, khafiifiyeyaasha dhiigga, iyo daawaynta fibrinolytic. Daawooyin kala duwan ayaa loo isticmaali karaa xaaladan maqaarka - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy waa xaalad naadir ah oo nabarro ay ka dhacaan labada lugood. Samaynta xinjirowga dhiigga ee xididdada yaryar ee dhiigga waxaa loo maleynayaa inay ka dhalatay xinjirowga oo kordhay iyo xinjirowga oo yaraada, oo ay weheliso dhaawac soo gaaray xuubka xididka. Waxay aad ugu badan tahay dumarka, gaar ahaan inta u dhaxaysa da'da 15 iyo 50. Joojinta sigaarka, daryeelka nabarrada, iyo isticmaalka daawooyinka sida kuwa dhiiga khafiifiya iyo daawooyinka platelet ayaa waxtar yeeshay.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
